I have the same issue, the only thing that seems to fix it for me is going Alt+Enter to go full screen and then hitting it again to go back to windowed mode. When it works, my mouse clicks are a quarter inch too low. It doesn't work often enough as I'd like. I did the service pack compatibility change and went to EQWin. Neither work consistently, although EQWin it happens less often.
I try to open other games up while I'm at camp but I can't. Just the act of switching back and forth between screens runs the risk of locking me up. I ask people every once in awhile in OOC with zero luck on any fixes.
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