Originally Posted by zanderklocke (Post 2481270)

Not best possible but some of my favorite duos are:

Wolverine and Gambit
Tom Hanks and Wilson
Pee Wee Herman and His Bike
Han Solo and Chewbacca
Roddy Piper and Keith David in They Live
Beavis and Butthead
Goku and Vegeta
Warf and Captain Picard
Fry and Bender
Simon Belmont and His Whip
Zack Morris and AC Slater
Bo Jackson on the Los Angeles Raiders and Bo Jackson on the Kansas City Royals
Mike Haggar and Cody
Pokemon Red and Pokemon Blue
Mario and Luigi
Big Daddy and Little Sister
Spider Man and Venom in Separation Anxiety on the Super Nintendo
Gordon Freeman and His Crowbar
Niko and Roman Bellic
Boba Fett and Dengar
Roger Murtaugh and Martin Riggs in Lethal Weapon
Doc Brown and Marty McFly
Vincent Vega and Jules Winnfield
Michael Jordan and Scottie Pippen on the '94 Bulls
Nagafen and Vox
Wolverine and Nightcrawler in the X-Men Arcade Game
Shadow and Interceptor in Final Fantasy VI
Jean Claude Van Damme and Donald Gibb in Bloodsport
Carl Weathers and Arnold Schwarzenegger in Predator
Taco Bell and Pizza Hut in the same fast food restaurant

Originally Posted by Lhancelot (Post 2481275)

LOL nice list man! I feel inspired to think of more dynamic duos...

Originally Posted by Sage Truthbearer (Post 2481232)

cleric + enchanter with a hasted, charmed pet (will out-dps any monk)

Originally Posted by Lhancelot (Post 2481289)

Ren and Stimpy
Garfield and Odie
Tom and Jerry
Spike the Bulldog and his son
Foghorn Leghorn and Henery
Mad Max and Goose
MacReady and Childs
Ripley and Newt
Indiana Jones and Short Round
Tyler Durden and The Narrator
Louis and Lestat

Just some I could think of just now.