What are you trying to accomplish?
Raids will have tash, malo, and hopefully bard debuffs on the mob, but being L60 also greatly helps.
In exp groups, as a mage or wiz I probably wouldn't toss more than a single nuke on each mob unless shit was hitting the fan and things needed to die now, regardless of resists.
In solo exp, the most efficient option has always been "lowest level mobs that are still dark blue."
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