From my experience on Monks it seems to make a big difference past level 45 for some reason?? Before that no big deal. Mostly based on weight tests. Seems you can be a pig as a Monk below 45 on here, after 45 it is a BIG penalty to be overweight with the damage you take.
It might just be mobs you fight at level 45 and above are just a LOT harder. I don't know for sure.
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