Should require LoS to start casting, but I seem to remember getting nailed by spells if the NPC got close enough to start casting even if I was running away. It was usually only the first cast because I would be out of range for the second one, unless the first brought me down to low.
I was on the wrong end of a wizard fight a few times where I would see them casting, try to stop after a few feet and they would land a spell with the same range as the one I was trying to cast, but I was still out of range until they ran 2 feet closer.
I kept LoS broken as much as possible running behind hills and walls because I knew if the started casting, they would always finish.
Memory is biased though, provide some proof this wasn't the case and we can look into it.
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