Preserve Neriak, Grobb and Oggok I'd say.
That gives you scope to do Freeport and Highkeep guards, Kaladim, Felwithe (better in the zone that doesn't zone to gfay, fear kite), Kelethin (outside rogue guild there's a wanderer, use that as a base and venture further back towards the lifts if you're killing well), Steamfont gnome guards, one at the junction, one outside the windmill - never been into Ak'Anon to try there.
Not so sure about Qeynos.
Don't kill the newbie area guards - they're mega buffed to protect noobs (2 guards at WFP gate, guards at the Kelethin lifts, outside Felwithe etc)
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