For Velious factions, you basically pick what you want to hunt.
Hunting giants tend to have the most benefit because killing them raises both Coldain and Dragon (CoV) faction, which means that after a while you'll be non-kos to Thurgadin and Skyshrine, and Kael is easy to invis through. There is also almost always multiple exp groups in Kael. Various giants in Kael drop quest items for Thurgadin armor sets. You can also join a raid guild to hunt in "Halls of Testing" in Temple of Veeshan (without harming your dragon faction) to get quest items for Skyshrine armor sets.
If you want to hunt dwarves there's not much available in the way of loot (obvious exception: councilor necklaces) and there aren't usually exp groups in Icewell. They don't drop any quest items for armor.
If you want to hunt dragons in Western Wastes you can get some pretty good necklaces / quest items / spell drops, but it's not going to be as good exp as hunting in Kael. If you want to raid North Temple of Veeshan you'll get quest items for Kael armor sets, but this usually requires joining a raid guild.
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