It depends on a lot of things.
-100 more strength will let you hit for more damage (higher 'max hit' from strength bonus)
-100 more strength will give you more attack and let you hit for a higher average DI (regardless of what the relative 'max damage' hit is)
On a low level blue or light blue (green) con where you're already hitting for a higher average DI (damage interval - ie more max hits more often) the 100 strength will not have the same impact as fighting higher con mobs closer to your level (or higher than you) in terms of your average DI. Mobs level and ac vs your level and attack will have a big impact on how hard you hit on the DI spread (1-20). For trivial mobs where you hit at or near max more often, the strength won't be AS important, but it'll still make you hit harder.
TLDR cliff notes:
-the difference between 200 strength and 100 strength at any given level will be pretty big.
-if you're a melee class tasked with dealing damage, you should make sure your strength is as high as possible.
-as you get way up there in levels, be aware that you can't go past 255 strength and high level strength buffs may or may not put you beyond the strength cap.
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