Not gonna happen.
Even with twinking so that you have proccing weapons and poisons and clicky CC items and reasonable gear, and having a knack for landing backstabs while solo, it'll still be absolutely brutal. Getting hit at all is going to mean tons of downtime to bandage. Even a FULL twink with a fungi and back when you could use ragebringer from 1 wasn't exactly great solo. I didn't go ALL out with clicky CC and working hard to finesse snare+fear procs and poisons... I mostly just let my gear brute-force through stuff while sometimes landing a strafe->backstab... but I still can't imagine anything would make it work untwinked.
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