Once you get a given resist stat to about 100, you have a strong chance to fully resist most spells of that type - if cast by another player. I'm guessing you're on the non-PvP server, though. Unfortunately, mobs seem to be able to land spells better than players.
Your best bet is probably to focus on Magic resist so you can at least have a chance of resisting really bad stuff like root and blind that could mean gruesome death.
You can cure disease and poison, or have a companion cure them, or use a cure potion; so resisting these two is less of a priority. Fire and cold would probably be the next priorities after magic. Wizard mobs in Guk and so on like to cast Ice Comet, so cold might be a good number two.
Beyond that, you can ask for resist buffs, and maybe switch in a few items for certain situations (like if you're about to fight some fiery or icy boss mob, you put on a Crown of the Froglok Kings). If you're in a situation where resists are important, like certain raids, you will hopefully be grouped with a friendly bard whose magical music provides the most powerful resistances.
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