A lot. Seething Fury is something like +70 ATK - and actually, Mrylokar's Dagger is probably something you'd bag for Ragebringer during any boss fight because lifetaps are a shitton of aggro. So I mean yeah in a straight up parse Mrylo's Dagger + Horn of Hsagra will outdamage Ragebringer + Horn of Hsagra, but that's providing the mob never turns around and starts beating you for siphoning 30 HP, killing your chances at backstabbing.
At the end of the day Ragebringer + Horn will net more total damage because they're just safer - the mob will always have its back to you and you'll hit all your backstabs. In a boss fight, it's not a question of whether you're hitting all of your backstabs - the first time it turns on you you're dead and you may have just wiped the raid. So ultimately Mrylo's Dagger is just a weapon that's amazingly awesome, but you'll probably only use it for less serious stuff like soloing, grouping, and lower-tier pushover bosses.
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