At higher levels when farming casters I like to use the 3 targetable dots and mez, and if you time it just right you should be able to basically lock a caster in place. Plan around the dot ticks, and start singing mez about 3-4 seconds after the dot damage is done because that is when the next round of dots are going to hit and break mez.
you should have no problem doing something like:
1) dot
2) mez
3) dot
4) mez
5) dot
It's all about timing. If your hp gets low at some point, let the dots run their course, then keep the mob locked with mez and twist in regen for yourself. If it's a mob with a pet I would recommend charming it first to kill the pet and not having to worry about it.
In tight spaces where I can't kite, I think I honestly prefer fighting caster mobs to melee mobs. A mob that can't do anything except begin to cast spells and never resolve them is a hell of a lot easier to defeat then one that is going to whack you everytime mez breaks.
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