Instruments do not determine if you miss a note or not when starting a song up.
Instruments are a modifier to a song's effectiveness. Let's say you have drums of the beast that lists "Percussion Instruments: 26". Any song you use that is percussion based will get a 2.6 multiplier to the song's effectiveness. So a spell like Tuyen's Chant of Frost (a dot) will do 2.6 times more damage each time it ticks.
Certain aspects of spells are not modified by instruments, like haste or mana regeneration. Checking out the bard page on the wiki should give a lot of helpful information on this.
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