I am not sure what you mean by humanoid but it varies by mob and your life. If you are critically low on life usually below 30% and a mob is in Melee range they don't tend to run. Undead pretty much as a whole don't run either. Animals and Guards tend to run at low life if they are single. Sometimes if both of them are beating on you after a charm break they won't start running until one of them is dead. Finally, even if a mob wants to flee if they are rooted they will always attack you if you go into Melee range.
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