[LiQuid]

I'm pretty susceptible to RSI joint pain in my fingers and wrists and when I push myself to play for a long time uninterrupted it can get pretty bad.

Agreed that braces (I use elastic bandages) and breaks are the best solution. Also I find the fact that I play so many different characters with different needs and I switch between them a lot. I did a few hours in Sky last week on Plush and the constant Canni dancing absolutely murdered me after a while. The next day I was in rough shape, so I spent some time on the cleric or wizard who has much less demanding buttons to push.

For elbows, I couldn't say. A brace should be mandatory. Maybe adjust your mouse sensitivity or DPI so that you can shoulder more motion in your wrist instead of your elbow.