I have Win 10x64 and it works perfect.
Start of my eqclient.ini
Code:
[VideoMode]
WindowedWidth=1920
WindowedHeight=1080
Width=1920
Height=1080
FullscreenBitsPerPixel=32
FullscreenRefreshRate=0
WinEQWidth=1920
WinEQHeight=1080
WidthWindowed=1920
HeightWindowed=1080
[Defaults]
Log=TRUE
WindowedMode=TRUE
Sound=TRUE
TextureQuality=2
Make sure you are running the launch titanium.bat and NOT using wineq2.
If you get it to work, make sure you change your max FPS in your options to 60 or so.
The program only works once you get into character select/ in game.
Make sure F3 isn't bound to something else. You can go into the program options and change which button you want to use. You can also try F4. Those are the two default buttons that will notify the program. It only works if Everquest has focus.