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Old 05-19-2019, 08:02 PM
Cecily Cecily is offline
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Join Date: Jan 2012
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You would think so, but there’s that first pass of the liver you have to consider. Oral route for estrogen drops its bioavailability to something like 5%, whereas transdermal, sublingual, and buccal routes are as good as you can get short of injections. I dissolve mine under my lip and it takes a couple hours to disintegrate and absorb, so I generally try to take my pills after I’m done eating so I don’t swallow any.

Here’s more information if you’re still curious: https://www.ncbi.nlm.nih.gov/m/pubmed/8530713/

Hope this helps!
Last edited by Cecily; 05-19-2019 at 08:05 PM..