I may be weird, but I put the spell slots to the number pad and it makes twisting very easy--either move with the left hand and twist with the right, or twist with the left and mouse with the right, when switching instruments.
Also, I put a tailored bag in my 8th inventory slot, and keep that open next to my primary and secondary weapon spots I moved to my action bar. That way, it only takes on inventory slot. I also put that inventory slot in the action bar, so I can open that bag with a key tap.
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