DSETUP.DLL is packed with anti-hax0r software called Themida. It's likely to create issues with running it under unintended conditions such as in Wine, moreover under MacOS.
First of all, I'd recommend trying the latest Wine builds, stable and dev.
If this doesn't work, try some kind of virtualization software for Mac, hoping your Mac is powerful enough that it will not kill P99 performance.
If all fails, honestly I'd just get a $300 Windows laptop that will run P99 just fine.
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