For grouping, I generally save my mana for snare, flamelick, harmony, dispell, root, chloro, etc. but if you're trying to burn something down quickly nuking between attacks is a good way to do it. It works pretty well with something slower like Woodsman Staff but less well with something like lupine dagger/swiftwind.
If you're soloing, leading with a dot or two can be effective and nukes can help in a pinch, but generally you're doing some combination of root/snare/shoot and face tanking depending on the level OR fear kiting animals in velious, so the situation for nukes will be few and far between.
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