Swapping: if you hold left click on your primary weapon slot, you can create a hotkey for that slot; do the same for secondary slot and for two top-level inventory slots and you can create a hotkey set that lets you swap instruments and weapons. It doesn't work with item slots inside bags; only top-level inventory slots. Of course, this means you should only be carrying six bags (some players carry even fewer).
This would probably be hotkey set 2 or 3, or at least something other than 1.
Note that you can cast songs by hitting Ctrl-1, Ctrl-2, etc.
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