Assuming it works as for enchanters, yes it's noticable.
A Dwarf will struggle getting any decent cha even with the glamour sword and max points into charisma. IIRC a dwarf with max charisma could would still have better melee stats than a Human or Erudite who went all sta (I'd go all cha). If you don't have a crown of narandi then kobold jester's crown makes sense and largely makes up for the poor charisma. Items like Matchless Dragon Bracers and Greaves of Distraction could help.
TLDR: Dwarf will be doable if you're twinking HARD, otherwise you will have a noticable difference when it comes to lulls.
A human should be a fair choice too if you don't wanna go HE. Almost same cha as HE and better stats.
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