For warrior?
Honestly I prefer rune weapons solo. Especially without regen tunics. I seem to be in the minority - most wars choose dps weapons to cut the fight shorter and self heal the remaining hp. Skean is handy for a self found though. The duration stun lets you get a few hits in the back, eliminating dodges and the like.
For a rogue it may be handy for increasing backstab opportunities without relying on ghoststep/sidewayslide or waiting for the mob to cast.
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Gorgen (Blue) - Agnostic Troll Warrior of the XXXI Dung
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