Tree of whispers a waste of time. You need to run a few to get sigils to start doing nightmare dungeons but the loot is bad for the time investment. Just turn the stuff in when you happen to fill the bar incidentally, imho, but never actively chase it down.
Helltides and Nightmare Dungeons are the best sources of gear and exp from my experience so those are the most important things. You can open upto 4 of the mystery chests during a helltide and they have lots of high quality drops usually.
World bosses aren't really good sources of loot but you need to do them for the upgrade materials to put sockets in things, and they don't take long.
For renown just make sure you get all of your potion charges and skill points asap and save the rest for when you're in WT4 since you'll get better drops and exp grinding out the last tiers then.
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