Yeah that's a tougher question for the weakest combination. The nice thing about EQ is the weaker races aren't weaker because they have a harsh penalty applied to them. They just lack strong racial traits.
The harshest penalties are applied to races that have something to compensate for it. The negative 20 fire resist on Trolls and Iksar plate restrictions are the worst, but they are countered by racial regen.
I would say Iksar Cleric would be meh. You don't have access to Donal's BP/Bracer, and the regen is helping you less than other classes, unless you have a manastone maybe.
For the strongest combo I agree with PatChapp. Ogre Enchanter would be awesome.
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