If you go a low wis class like gnome with all cha you'll struggle for mana in Classic. I doubt it'd affect grouping but soloing could suck, for instance not sure you'd have the mana to nail specters at relevant levels. Soloing in guk would be a lot harder too if not impossible, unless maybe you could get your hands on a Dawnfire.
To me cha at day 1 seems worth any possible struggle though if you go the distance and get guise and firepot bind for a main character cleric.
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