+HP +Mana. Always works. HP AC on a caster will run out sooner. Less mitigation from AC and less defense etc.
Skillz and situational awareness will win out.
A twinked monk in the hands of a total twonk would certainly survive. A skilled player with the same gear? Better.
Same with casters but I think skillz will count more here. Just my seat-of-the-pants feeling.
TL;DR Twinking for a caster is +HP +Mana AND knowledge of the class.
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