Root rotting is the least efficient of the three methods by far, but it's also the most generally applicable and safest. Doing nothing but root rotting to 60 sounds like it would be a real slog. You don't kill very fast and you spend a lot of time sitting. The epic and getting a Drones of Doom clicky both help.
It's great for filling in those awkward levels without other good options, good for killing whatever random mob you need for a quest or when farming some item. Great for when you feel like logging in for a brief session. Probably half my xp from 40 to 50 was root rotting. The -100 modifier on the magic line of dots is really nice too.
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