I'm running Xp Pro SP2 and I don't see AFFINITY listed as an option under Start... if I try this command line it returns "Invalid switch - "affinity"" so perhaps this is a Vista thing?
What works for me is the following in Target:
C:\Path to EQ\EverQuest\RunFirst.exe "eqgame.exe patchme"
with the path to EQ in the Start In field.
You can download RunFirst from
http://www.activeplus.com/Products/RunFirst - it's free.
Regards,
Mg