I think the overarching point here is if you need to join a group or not. If you're LFG and bound by where the existing groups are already then you'll be needing to just follow the herd...making about half the possible zones unpossible :P
Agreed on the former popularity of Mistmoore, I remember everything camped... CE camped, so a group or even two would move in and try and do some of the more tricky stuff by Dhamp or do the gypsies if CE's group wasn't able to reach that far.
Unrest is a realistic option in the basement as a trio, a tank, cleric and dps is all you really need. If the tank is a paladin, that's good for extra dps. If the cleric is one of two healers he can throw some nukes in. Things open up for groups if undead is involved. Definitely too slow for a full group, but a knowledgable trio can make quick work of the basement
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Alternatives? Sol B entrance is probably doable. Overthere used to be a popular zone for the mid-30s...not sure at the moment. If you can "bring your own group" to a zone you shouldnt rule out Nurga Mines (off FM)...though Droga is a pathing nightmare.
At 38-40 I solo'd the festering hags in Unrest as a cleric. Some well placed lulls/trial and error and they're broken and very nukable (keep a symbol up). There's no reason why a 35ish cleric and another dps couldn't hold those down if the basement is camped.