This actually just happened to me recently.
I started getting bored of hunting WC and Oasis around level 18, so I got a wild hair up my butt and decided to branch out a bit. I settled into East Karana very nicely and bound myself on the Gorge/EK zoneline. After finally hitting level 20 in about one morning's work I had amassed a good bit of silk and coins and decided to make my way back to Neriak to unload my goods.
Not being one to go scrounging around for buffs where others are hunting I decided to just hike it back under my own power. I made it to EC with no trouble, sold my goods, and headed finally to Neriak to bank. Since I hadn't been in Nektulos for a good 5-6 levels I wanted to check and see what the halflings in Nektulos forest were conning.
I saw a blue con and squared off against it with no pet. What could go wrong, right? Well I had made the stupid decision of picking the "Leatherfoot Medic". To make a long story short, the bastard chain stunned my dumb ass into oblivion and wiped the forest floor with me and voila! I found myself standing naked as a jaybird all the way back in EK at level 19. Let's just say it wasn't a very happy CR
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