I tried every trick in here and others, and still had occasional slow run issues. What fixed it for me was turning the sky off and disabling vertex shader, probably something to do with shitty ATI drivers.
So, if you're having persistent slowness issues, try turning off the sky under options->display.
and in eqclient.ini
TextureQuality=1
VertexShaders=FALSE
20PixelShaders=TRUE
14PixelShaders=TRUE
1xPixelShaders=TRUE
MultiPassLighting=FALSE
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