I've always gone by the rule: lowest delay in main hand, best ratio in off hand.
My current combo is Jade Mace 9/18 (50% ratio) in main hand and Adamantite Club 15/25 (60% ratio) in off hand.
Knuckle Dusters are 14/28 (50% ratio) but are quite slow. I would use KDs in off hand and find something with a lower delay for main hand.
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