Enh, it really changes on a fight by fight basis, and your raid/group composition as well, a good example of a mana>hp situation would be if your raid is light on shamans and you're doing some boss that is difficult to slow that also does heavy AoE, like say you're doing Dagarn for example, say you have to cast malo+slow 7 times at the start of the fight which is already 2100 mana dumped right there. And by the time it's slowed everyone in your group is sitting at 30% or whatever. Just an example but it happens occasionally depending on how many shamans are in your raid.
In that situation it's preferable to still have a bunch of mana left to cast 6 torps on your group and yourself or else your melee will just have to sit around hiding while you canni up, probably sending tells to eachother about your mother.
But yeah mana isn't relevant for most things. There's just a few tho where all the difficulty of the encounter is based on the initial "sprint" at the beginning, and the time commitment of casting canni is troublesome durring that sprint.
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