In any situation where you are facing a mob (or it has a DS) a good 2hander easily beats slightly better 1handers. It's also less aggro for group situations, even if the damage is more sporadic.
Personally if its a 5-10% difference I'd be tempted to go with less aggro unless you have a lock on that or plan to help rooting for prox aggro. It also opens you up to more efficient casts between swings. I'm sure my tune would change if I had epics
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