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Originally Posted by imperiouskitten
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this sounds mostly right but -- how do you account for the durability of the vaccination if nothing is encoded permanently? where's the perma change? I thought the mRNA was used for the dna polymerase to transcribe into DNA in this case, not for it to be made into a protein ^^
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The durability comes from your immune system response to the viral antigen proteins that are produced using the mRNA, like any other vaccine. Specialized lymphocytes remember the antigens for as long as the rest of your life, and wandering macrophages will patrol the ghettos of your body racial profiling for covid.
mRNA is used by ribosomal subunits to make proteins directly. DNA polymerase is used to make DNA copies of other DNA in the nucleus. RNA polymerase, on the other hand, reads specific genes on your DNA genome and makes an mRNA transcript from that gene. In this case the mRNA is just being introduced from outside the cell, borne by vaccine, packaged in a small lipid nanoparticle.
It's just a different method of introducing the viral parts into your body. No actual virus involved so no chance of infection, and easier to mass produce.