I think it depends on how much plat you have. If this is your first toon and you have a few thousand plat to your name I would say stick with Rune III. If this is an alt and you have 10k+ then the cost of peridots is worth it.
Rune IV = more hp absorb = less dying = you level faster = cost of peridots become trivial. Rune IV also lasts around 20 minutes longer.
Once you get Rune V I suggest never using Rune III or Rune IV again regardless of how much plat you have. Always recast Berseker Spirit early if possible, if you get hit once or twice but still have Berserker Spirit up then recast it to minimize how often you will have to cast Rune V.
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