You use the best weapons you have access to. That may be a 2-hand weapon or it may be 1-hand weapon plus a shield. Using a shield for its own sake is seldom necessary. This isn't World of Warcraft where shields offer a huge bonus to durability; in this game their impact is modest at best.
My Paladin uses a 1H/shield setup simply because that's the best he has. My Shadow Knight uses mainly a 2H. He keeps a 1H/shield in the bag but I seldom use it except where I'm running through an area expecting to take hits without fighting back such as swimming through Siren's Grotto. If I didn't carry a shield at all I wouldn't likely miss it.
Danth
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