As long as you can invis yourself in Qeynos, being KOS to the guards isn't terrible. Being KOS to the Order of Three (or whatever the magic users are) is a royal pain. They wander around and nuke you really hard while you're in the bank.
You can gain your guard faction back by doing the Rohand's Brandy quest. 16 stacks of brandy took me from scowling to indifferent.
Don't forget to invis yourself when getting ported if the druids don't like you.
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