Really think you need to new install Windows 10 too.
I have also the RX6800 and im pretty sure assuming a Windows patch in combination with the graphic card caused this.
After that with the exact same copy of the game on the new installed windows in compatibility mode no more run time error game running good as before no lags for me (but never had those). I did not install Graphic card software from AMD again this time (had it on before).
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