Running P99 from USB Drive

[Beldon]

I have heard some talk about people doing this and wanted to get some more information.
I am usually playing on 1 of 3 machines at the house depending on the situation and am constantly having to adjust/tweek my interface to match when I swap over to a different PC.
Is it possible to install this on a Flash drive and just play off of that regardless of the PC I am using?
Or is an easier fix just to find the correct files related to the GUI/layout and keep them available on the network?