Mouse Issue with Titanium Client

[MasterGeoffrey]

Don't see where this could belong anywhere on the other forums, so I'm plopping it here.

I run the Titanium client, windowed mode, 1920x1080, and I have two monitors. Every now and then (haven't isolated why, yet), I have this problem where my mouse cursor is pointing directly at something, but the window seems to think it's somewhere else either to the right or down of the mouse. For example, I'll click directly on a spell gem, nothing happens. I move my mouse to the left of the gem and click, and the spell starts off. Only way I seem to be able to fix it is to close the client all the way down and load it back up.

Has anyone else experienced this problem?