I will be on seroquel or quetiapine fumarate soon. It should be more effective PRN than lithium 24/7. I have my doubts. Hence the angst. The name of the drug is pretty stupid but who knows. That has nothing to do with its actual effect.
Quote:
Quetiapine has the following pharmacological actions:[49][50][51][52][53][54][55][56]
Dopamine D1, D2, D3, D4, and D5 receptor antagonist
Serotonin 5-HT1A receptor partial agonist, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 receptor antagonist, and 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptor ligand
α1- and α2-adrenergic receptor antagonist
Histamine H1 receptor antagonist
Muscarinic acetylcholine receptor antagonist
This means quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties.[57] Quetiapine binds strongly to serotonin receptors; the drug acts as partial agonist at 5-HT1A receptors.[58] Serial PET scans evaluating the D2 receptor occupancy of quetiapine have demonstrated that quetiapine very rapidly disassociates from the D2 receptor.[59] Theoretically, this allows for normal physiological surges of dopamine to elicit normal effects in areas such as the nigrostriatal and tuberoinfundibular pathways, thus minimizing the risk of side-effects such as pseudo-parkinsonism as well as elevations in prolactin.[60] Some of the antagonized receptors (serotonin, norepinephrine) are actually autoreceptors whose blockade tends to increase the release of neurotransmitters.
At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker. When the dose is increased, quetiapine activates the adrenergic system and binds strongly to serotonin receptors and autoreceptors. At high doses, quetiapine starts blocking significant amounts of dopamine receptors.[50][61] Off-label prescriptions, e.g. for chronic insomnia, of low-dose quetiapine is not recommended due to the harmful side-effects.[62]
When treating schizophrenia, antagonism of D2 receptor by quetiapine in the mesolimbic pathway relieves positive symptoms and antagonism of the 5HT2A receptor in the frontal cortex of the brain relieves negative symptoms.[15][63][64] Quetiapine has fewer extrapyramidal side effects and is less likely to cause hyperprolactinemia when compared to other drugs used to treat schizophrenia, so is used as a first line treatment.[65][66]
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Per wikipedia for whatever that is worth. I don't trust my doctor or have a fucking clue how it is going to work but there it is... I'm going to try it. This same doctor proscribed the lithium for me like a year and a half ago. The FDA says she's not supposed to proscribe it as a sleep aid or sedative. I guess she still wants to treat the major depressive disorder without prescribing both pills for anxiety and depression. And the VA has been legally hammered to shit by ignorant and corrupt corporate shills for giving out tranquilizers like lorazepam.
I honestly think some decent ativan at night and PRN so I don't sleep in a furious ball of kill you + some gabbapentin would do better for me. But that's not indicated by my borderline personality disorder. I guess or whatever it is. The docs are trying to still treat the 'depression'. Which IMO is caused by anxiety and inability to connect emotionally or socialize with other people in a safe and kind genuine way, and probably will never be because my brain development and neurochemistry is nothing like what it should be, or will ever be. In any sane kind, normal human, who hasn't had their flesh ripped off. I also have a lot pain caused by trauma and skeletomuscular problems. Because I put my body through some intensely dumb shit (other than transitioning). I use to be a real hardcore motherfucking bad-ass and it's taken it's toll. Treating that would give me room to breathe and cope with my enlightened ways.
A big part of why I don't go outside and talk to people is because I want to hurt them badly. I don't like them and they make me really furious with their biological instinctual mammalian failings. Short of being mind wiped some how. And literally losing my personality. I doubt that is fixable. It just is who and what I am. Nature designed us this way so we wouldn't instantly die when a scary tiger showed up we could hiss at it and make it think twice and maybe back off and eat the dumb ass who fell over paralyzed in fear.
Theophalyn is supposed to calm people down and help them breathe but I went apeshit on it as a child. My mom has very atypical responses to most medications and anesthesia. When I am pissed off I am very very hard to put down chemically. I can stay awake, very hard to hypnotize, not even when I am willing, etc.
06-11-2020, 02:49 PM
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