Quote:
Originally Posted by Uthgaard
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Two tums isn't going to make a damn bit of difference. pKa difference is such that even if you did manage to raise the pH of your stomach, you're still only going to protonate 1 in every 10000000 molecules. And that's not going to influence the absorption.
Beside that, hepatic metabolism is horrible. Chewing up painkillers is amateur white trash junkie shit.
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to be honest, the opiates + tums for potentiation thing is a common technique that i have heard enough times that i never bothered to verify if it was true. doing some googling around, it seems that raising stomach pH may or may not affect opiate absorption. one source even said that it can decrease bioavailability.
if it is indeed just an urban legend, its roots may come from the fact that a different class of antacids actually do potentiate many opiates. cimetidine (otc trade name tagamet) does not attempt to directly raise stomach ph, but rather inhibits stomach acid production. cimetidine happens to be a CYP2D6 inhibitor, the liver enzyme that metabolizes many common opiates... thus prolonging the high.
06-20-2014, 06:37 PM
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