Best 3 Combination?
 

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Are you willing to play a shadowknight? Is the enchanter comfortable with charming? If so, I think that might work for the three of you.

Shaman/druid/cleric
Enchanter
Warrior/SK/Pally

Each combination have their ups and downs.

Enchanter, Druid, Paladin.

My god, I feel like I answer this question once every other week...

Reason:
heal
slow
haste
nuke
dot
charm
root
snare
mez
regen
mana regen
strength, hitpoint, int/wis, agility and AC buffs
debuffs
damage shields
invis
invis vs. undead
massive stunlock
sow
teleports
quick evac
lull
Runes
resurection
banes versus undead as well as animals, summoned creatures and plants (come Kunark)
all resist types covered
Mana leeching spells (multiple come Kunark)
tracking


Need I say more?

Any outdoor zone, any type of dungeon, underwater... You name it, this trio can do it!
And once Kunark and Velious are out druid teleports become key!!!

necro/shaman/monk

truly fantastic DPS coupled with great mana regen! can also split, slow will decrease the need for heals, incredible buffs and snare those runners. Necro can heal and/or mana battery if needed and even root-mez. If you're willing to get a few essence emeralds (in kunark at least) you'll be able to do your own corpse summons and rezzes if things go awry.

the one thing that may hurt are caster mobs, the necro stun is very short duration and has quite a recast timer.

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I don't understand why that would matter.

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If you are leveling with friends it might even be better to have a mix of good and evil. That way no matter where you are at least 1 person could travel into the city to sell, bank, get items that can't be purchased elsewhere.

I only see advantages to having various factions in your group.

Also if you have a chanter in your trio (agnostic of course) then you don't even need the variety.

If you don't want to play an enchanter you could sub in a bard. Not as good but you get haste and mana regen. That and you can sit back and scream at them to sing for their supper.