I carry a Fashsmasher on my Epic monk and I will attack with my fists and then every 5 seconds or so very quick click in and click out my Facesmasher. Basically gives my Monk the Backstab ability. Nothing sweeter than seeing a double attack for 500+ damage and then back to fists of fury.
Unless you have a really high damage weapon it probably isn't worth clicking in 2h damage. IFS might be high enough at 38, but honestly its probably more of a hassle than an upgrade in DPS. Damage shields will seriously wreck you though and even though that is a very niche situation you should always carry a 2hander for when it happens. Hell a Wu Quivering Staff is better than fists on a damage shield TBH
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