If I recall, they should do 2 cycles of their path before despawning. At least that is what I read somewhere about some of the other special clockwork rats for the wizard quest. Though that definitely wasn't the behavior I was seeing with most of the scrubbers, I had a few of them targeted for quite a while without them ever despawning. At least one spawn does seem to despawn though, because I was seeing Duster V, Duster X and Scrubber IV all showing up from time to time following the same path along the lake and they all come from the same spawn point that should be shared with the npc for this quest.
I suppose it is definitely possible that I am just having extremely bad luck with this, but a level 4 quest shouldn't take several hours of waiting around, that nonsense should be saved for higher level quests, heh. =P
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